Here are some of my top suggestions:
Dr. Case Troutman of Midlife ReMDy
Midi Health an online platform that will use your insurance (typically) CANNOT prescribe testosterone gel because PA does not allow testosterone to be dispensed via telehealth.
4th Tree Health Direct Primary Care
The Menopause Society Website can help you find a trained provider in your area. Make sure you vet your provider properly most clinicians even OB-GYN's are NOT trained in midlife hormones.
Discover Pelvic Health and Wellness Megan Miller, PT a pelvic floor physical therapist who is knowledgeable about perimenopause and menopause.
Some things to remember cited from Dr. Kelly Casperson's work Menopause Moment:
(Dr. Kelly Casperson – The Menopause Moment)
What estrogen does:
Supports brain function, mood, and sleep
Maintains bone density and muscle
Protects cardiovascular health
Keeps vaginal, vulvar, and urinary tissues healthy
What happens in perimenopause:
Estrogen becomes erratic (highs and lows, not a steady decline)
Fluctuations drive symptoms like:
Hot flashes
Sleep disruption
Mood changes
Brain fog
Vaginal dryness and urinary symptoms
Casperson key point:
Estrogen is a whole-body hormone, not just a reproductive one.
(Dr. Kelly Casperson – The Menopause Moment)
What progesterone does:
Calms the nervous system
Supports sleep quality
Balances estrogen’s effects on the uterus
Helps with cycle regulation
What happens in perimenopause:
Progesterone is often the first hormone to decline
This creates relative estrogen dominance, even if estrogen isn’t “high”
Common symptoms:
Anxiety
Insomnia
Irritability
Heavier or irregular periods
Casperson key point:
Many early perimenopause symptoms are progesterone loss, not estrogen deficiency.
(Dr. Kelly Casperson – The Menopause Moment)
What testosterone does (in women):
Supports muscle mass and strength
Contributes to energy, motivation, and confidence
Plays a role in libido and sexual response
Supports bone density
What happens in perimenopause:
Testosterone slowly declines with age
Loss contributes to:
Decreased muscle
Lower energy
Reduced sexual desire
Reduced resilience to stress
Casperson key point:
Testosterone is not a male hormone — women need it for physical and sexual health.
Why Estrogen Matters (It’s Everywhere)
(Dr. Kelly Casperson – The Menopause Moment)
Estrogen works by binding to estrogen receptors throughout the body, including the brain, bones, muscles, heart, bladder, vulva, vagina, and pelvic floor.
What changes in perimenopause:
Estrogen levels become erratic rather than steadily declining
Estrogen receptors receive inconsistent signaling
Tissues lose predictability, resilience, and repair capacity
Effects of changing estrogen signaling:
Brain: mood changes, anxiety, brain fog, sleep disruption
Muscle & bone: reduced muscle maintenance and bone density
Pelvic & urinary tissues: dryness, irritation, urgency, leakage
Cardiovascular system: gradual loss of protective effects
FDA Update on Black Box Warnings (2025)
The FDA has removed the black box warning from many menopausal hormone therapy products — including systemic estrogen and estrogen-progestogen combinations — to align labeling with current evidence. HHS
This reversal corrects decades of fear based on early WHI interpretations and may improve access to evidence-based care. HHS
Some specific risks (e.g., endometrial cancer with unopposed estrogen in women with a uterus) remain part of ongoing safety guidance. STAT
Women should talk with a qualified menopause clinician to understand personalized benefits and risks.
The problem was never estrogen — it was how the data was interpreted and communicated.
✔️ The FDA has initiated removal of the black box warning from most hormone replacement therapy products used for menopause.
This includes many estrogen-containing therapies — both estrogen alone and estrogen-plus-progestogen formulations — not just low-dose vaginal estrogen.
✔️ News reports state the FDA’s recent action removes the strictest warning from “hormonal menopause therapies,” suggesting that the broadest warnings about risks like cardiovascular disease, breast cancer, and dementia are being pulled off labels. KSAT
Some risk information is not entirely erased, particularly for specific products or populations:
✔️ The warning about endometrial cancer risk in systemic estrogen-alone therapy for women with an intact uterus is likely to remain — because unopposed estrogen can stimulate the uterine lining and increase that specific cancer risk, and professional guidance continues to emphasize the need for progesterone in such cases. STAT
✔️ Systemic (oral/patch) vs vaginal estrogen still differ in risk profiles — and experts caution that label changes do not mean all risk disappears for every individual. PBS
The FDA’s decision comes after a decades-long re-evaluation of hormone therapy risks and benefits and aims to correct fear-driven labeling based on early WHI interpretations that outlived the science.
Removing the box warning is intended to reduce stigma and barriers to appropriate menopause care. Healthline
Some experts still urge individualized risk assessment, especially for systemic therapy, because different formulations and delivery methods have different risk profiles. -PBS, Other Sources
